郵箱: ghhu@sinh.ac.cn
電話: +86-21-54923296
所屬部門: 中國科學院腫瘤與微環境重點實驗室
2017-至???今:中國科學院上海營養與健康研究所,研究員,院長助理,副所長(主持工作)
2009-2016年:中國科學院上海生命科學研究院/上海交通大學醫學院健康科學研究所,研究員
2014-2016年:中國科學院上海生命科學研究院/上海交通大學醫學院健康科學研究所,副所長
2011-2014年:中國科學院上海生命科學研究院/上海交通大學醫學院健康科學研究所,所長助理
2009-2009年:美國普林斯頓大學分子生物系,Associate Research Scholar
2005-2008年:美國普林斯頓大學分子生物系,博士后
2000-2005年:美國羅格斯大學,分子遺傳學,博士
1996-2000年:清華大學,生物科學與技術系,學士
腫瘤轉移與微環境調控
1. 轉移的微環境調控機制。腫瘤轉移是癌癥致死的主要原因。癌細胞對其所處微環境的適應及改造對轉移過程有重要影響。我們主要研究癌細胞與轉移微環境的互作機制,以及這些互作對腫瘤轉移能力、轉移的器官特異性、癌細胞的轉移休眠/重激活狀態的調控作用,并進一步發現有效預測腫瘤轉移的分子標志物以及靶向腫瘤-微環境互作的策略。
2. 腫瘤干細胞與轉移。腫瘤干細胞一般被認為是癌癥發生、抗藥及復發的“元兇”,但是腫瘤干細胞與轉移的關系尚不清楚。我們主要研究腫瘤干細胞在轉移中發揮的作用及調控機制,分析腫瘤干細胞的異質性,不同干細胞亞群的轉移及調控,腫瘤干細胞與轉移微環境的互作等,以期發現通過靶向腫瘤干細胞抑制轉移的方法。
3. 腫瘤代謝調控與轉移。腫瘤的Warburg效應已經引起廣泛關注。我們主要研究在轉移過程中的糖脂代謝調控,包括癌細胞自身的代謝異常模式、代謝微環境對癌細胞轉移能力以及轉移器官特異性的調控作用等。
1.?Wu Q, Tian P, He D, Jia Z, He Y, Luo W, Lv X, Wang Y, Zhang P, Liang Y, Zhao W, Qin J, Su P, Jiang YZ, Shao ZM, Yang Q*, Hu G*. SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches. Cell Res 2023 Jun;33(6):464-478
2.?Wang Y, Jia Z, Liang C, He Y, Cong M, Wu Q, Tian P, He D, Miao X, Sun B, Yin Y, Peng C, Yao F, Fu D, Liang Y, Zhang P*, Xiong H*, Hu G*. MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation. Cell Discov 2023 Feb 21;9(1):20
3.?He Y, Luo W, Liu Y, Wang Y, Ma C, Wu Q, Tian P, He D, Jia Z, Lv X, Ma YS, Yang H, Xu K, Zhang X, Xiao Y, Zhang P, Liang Y, Fu D*, Yao F*, Hu G*. IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer. J Clin Invest 2022 Oct 17;132(20):e157917
4.?Ma C, He D, Tian P, Wang Y, He Y, Wu Q, Jia Z, Zhang X, Zhang P, Ying H, Jin ZB, Hu G*. miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression. Proc Natl Acad Sci U S A 2022 Feb 8;119(6):e2114006119
5.?Xiao Y#, Cong M#, Li J, He D, Wu Q, Tian P, Wang Y, Yang S, Liang C, Liang Y, Wen J, Liu Y, Luo W, Lv X, He Y, Cheng DD, Zhou T, Zhao W, Zhang P, Zhang X, Xiao Y, Qian Y, Wang H, Gao Q, Yang QC, Yang Q, Hu G*. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell 2021 Mar 8;39(3):423-437.e7
6.?Li Y, Lv Z, Zhang S, Wang Z, He L, Tang M, Pu W, Zhao H, Zhang Z, Shi Q, Cai D, Wu M, Hu G, Lui KO, Feng J, Nieto MA, Zhou B. Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell 2020 Sep 14;54(5):593-607
7.?Zhang P, Liu Y, Lian C, Cao X, Wang Y, Li X, Cong M, Tian P, Zhang X, Wei G, Liu T*, Hu G*. SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation. Nat Commun 2020 May 19;11(1):2487
8.?Cong M, Wang Y, Yang Y, Lian C, Zhuang X, Li X, Zhang P, Liu Y, Tang J, Yang Q, Zhang X, Xiong H*, Hu R*, Hu G*. MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination. Nat Cancer 2020 Jan 20;1(2):222-234
9.?Ma Q, Wu K, Li H, Li H, Zhu Y, Hu G, Hu L, Kong X. ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression. Sci Rep 2019 Dec 27;9(1):20021
10.?Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, Yu J, Zhang X, Yang Q*, Hu G*. Differential effects on lung and bone metastasis of breast cancer by Wntsignalling inhibitor DKK1. Nat Cell Biol 2017 Oct;19(10):1274-1285
11.?Huang H, Zhang W, Pan Y, Gao Y, Deng L, Li F, Li F, Ma X, Hou S, Xu J, Li P, Li X, Hu G, Li C, Chen H, Zhang L, Ji H*. YAP suppresses lung squamous cell carcinoma progression via deregulation of the DNp63-GPX2 axis and ROS accumulation. Cancer Res 2017 Nov 1;77(21):5769-5781
12.?Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J*. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest 2017 Apr 3;127(4):1284-1302
13.?Hu J#, Li G#, Zhang P, Zhuang X, Hu G*. A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis 2017 Mar 16;8(3):e2679
14.?Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q*, Hu G*. The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene 2017 Feb 16;36(7):989-998
15.?Yu PF, Huang Y, Xu CL, Lin LY, Han YY, Sun WH, Hu G, Rabson AB, Wang Y, Shi Y*. Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis. Oncogene 2017 Feb 9;36(6):840-849
16.?Yu J#, Lei R#, Zhuang X, Li X, Li G, Lev S, Segura MF, Zhang X, Hu G*. MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun 2016 Dec 20;7:13884
17.?Chen X, Cao X, Sun X, Lei, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, HouY, Wang M, SiebenlistUt, Chin E, Wang Y, Cao L, Hu G*, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death Dis 2016 Dec 1;7(12):e2508
18.?Liang Y#, Hu J#, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X, Hong D, Yang Q, Hu G*. Epigenetic activation of TWIST1 by MTDH promotes cancer stem-like Cell traits in breast cancer. Cancer Res 2015 Sep 1;75(17):3672-3680
19.?Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G, Sun Y*. New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med 2015 Mar 5;13:45
20.?Wei Q,Lei R, Hu G*. Roles of miR-182 in sensory organ development and cancer. Thorac Cancer 2015 Jan;6(1):2-9
21.?Wan L, Hu G, Wei Y, Yuan M, Bronson RT, Yang Q, Siddiqui J, Pienta KJ, Kang Y*. Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 2014 Sep 15;74(18):5336-5347
22.?Zhang N, Wang X, Huo Q, Sun M, Cai C, Liu Z, Hu G, Yang Q*. MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene 2014 Jun 12;33(24):3119-3128
23.?WangY, Lei R, Zhuang X, Zhang N, Pan H, Li G, Hu J, Pan X, Tao Q, Fu D, Xiao J, Chin E, Kang Y, Yang Q*, Hu G*. DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest 2014 Apr;124(4):1646-1659
24.?Zhang N, Wang X, Huo Q, Li X, Wang H-Y, Schneider P, Hu G*, Yang Q*. The oncogene metadherin modulates the apoptotic pathway based on thetumor necrosis factor superfamily member TRAIL in breast cancer. J Biol Chem 2013 Mar 29;288(13):9396-9407
25.?Lei R#,Tang J#, Zhuang X, Deng R, Li G, Yu J, Liang Y, Xiao J, Wang H-Y, Yang Q, Hu G*. Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene 2014 Mar 6;33(10):1287-1296
26.?Lin B#, Wang Y#, Wang Z, Tan H, Kong X, Shu Y, Zhang Y, Huang Y, Zhu Y, Xu H, Wang Z, Wang P, Ning G, Kong X*, Hu G*, Hu L*. Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort. PLoS One 2014 Feb 28;9(2):e90215
27.?Liang Y, Wu H, Lei R, Chong RA, Wei Y, Lu X, Tagkopoulos I, Kung S-Y, Yang Q, Hu G*, Kang Y*. Transcriptional network analysis identifies BACH1 as amaster regulator of breast cancer bone metastasis. J Biol Chem 2012 Sep 28;287(40):33533-33544
28.?Jin L#, Zhang Y#, Li H, Yao L, Fu D, Yao X, Xu L*, Hu X*, Hu G*. Differential secretomeanalysis reveals CST6 as a suppressor of breast cancer bone metastasis. Cell Res 2012 Sep;22(9):1356-1373
29.?Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X*. ACAP4 cooperates with GRB2 to orchestrate EGF-stimulated integrin beta1 recycling in cell migration. J Biol Chem 2011 Dec 23;286(51):43735-43747
30.?Liang Y, Fu D, Hu G*. MTDH: An emerging key regulator of malignant progression in multiple cancers. Thorac Cancer 2011 Nov;2(4):143-148
31.?Korpal M, Ell B, Buffa F, Khan Z, Blanco M, Hua Y, Wei Y, Hu G, Garcia B, Ragoussis J, Singh M, Harris A, Kang Y*. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med 2011 Aug 7;17(9):1101-1108
32.?Shan J#, Budijono S#, Hu G#, Yao N, Kang Y, Ju Y*, Prud’homme R*. PEGylated composite nanoparticles containing upconverting phosphors and meso-tetraphenylporphine (TPP) for photodynamic therapy. Adv Funct Mater 2011 May 5;21(13):2488-2495
33.?Lu X, Yan C, Yuan M, Wei Y, Hu G, Kang Y*. In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropicmetastasis of breast cancer. Cancer Res 2010 May 15;70(10):3905-3914